Their remarkable ability to adapt to new hosts and evade bacterial defenses makes them attractive candidates for therapeutic applications, yet their behavior remains difficult to predict. Our laboratory seeks to uncover the molecular and genomic principles that govern phage adaptability, host-range evolution, and therapeutic performance. By understanding the rules that shape phage infection and evolution, we aim to transform phage biology from a largely descriptive field into a quantitative science capable of enabling principled engineering of phage therapeutics.​​​​

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A central strategy in our work is the development of experimental systems that allow systematic interrogation of phage sequence–function relationships at scale.

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Using high-throughput genome engineering, deep mutational scanning, barcoded deletion libraries, and next-generation sequencing, we generate large libraries of phage variants and measure their fitness across diverse bacterial hosts and environmental conditions.